Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report

Obelleiro Campos Xabier Alexandre

doi:doi:10.11648/j.plm.20230702.11

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Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report

Obelleiro Campos Xabier Alexandre

Published in Pathology and Laboratory Medicine (Volume 7, Issue 2)

Received: 14 April 2023 Accepted: 28 April 2023 Published: 18 September 2023

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Abstract

Background: Sulfonamides are a commonly prescribed class of antibiotics for the treatment of urinary tract infections (UTIs). Sulfadiazine, in particular, has been associated with the formation of crystals in urine, which can lead to kidney stones and urinary tract obstruction. Objective: To report a case of sulfadiazine urine sediment in a patient with a history of recurrent UTIs. Method: We present a case report of a 45-year-old female with a history of recurrent UTIs who presented with the presence of sulfadiazine crystals in her urine sediment. The patient had been prescribed sulfadiazine for a recent UTI and had discontinued the medication as directed by her physician. Urine analysis revealed the presence of numerous sulfadiazine crystals, as well as leukocytes and bacteria. The patient was treated with antibiotics and instructed to drink plenty of fluids. Follow-up urine tests showed the disappearance of the sulfadiazine crystals. Results: The presence of sulfadiazine crystals in urine sediment was detected on routine urine analysis in a patient with a history of recurrent UTIs who had been prescribed sulfadiazine for a recent UTI. The crystals disappeared on follow-up urine tests after treatment with antibiotics and increased fluid intake. Conclusion: Sulfadiazine urine sediment is a rare complication associated with the use of sulfonamides for the treatment of UTIs. Clinicians should be aware of this potential complication and monitor for the presence of sulfadiazine crystals on urine analysis in patients who have been prescribed sulfonamide antibiotics. Appropriate management, including discontinuation of the medication and increased fluid intake, can prevent the development of kidney stones and urinary tract obstruction.

Published in	Pathology and Laboratory Medicine (Volume 7, Issue 2)
DOI	10.11648/j.plm.20230702.11
Page(s)	24-27
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Sulfadiazine, Crystalluria, ITU, Urinary Disease

References

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[2]	Frohman EM, Lerner AJ. Sulfadiazine crystalluria: a rare complication of sulfonamide therapy. Arch Intern Med. 1983; 143 (3): 569-571. doi: 10.1001/archinte.1983.00350030133028. PMID: 6838719.
[3]	Ismailos G, Kottaridi C, Karapanagiotou A, Tzavara C, Ntasi G, Koulouris C, et al. Sulfonamide crystal-induced acute renal failure: a case report. Cases J. 2009; 2: 79. doi: 10.1186/1757-1626-2-79. PMID: 19108725; PMCID: PMC2629426.
[4]	Johnson CE, Tucci V, Sommer FG, Betten DP. Sulfadiazine crystal-induced ureteral obstruction: a case report. J Emerg Med. 2007; 32 (1): 35-38. doi: 10.1016/j.jemermed.2006.07.034. PMID: 17239734.
[5]	Zaki SA, Akhtar J, Al-Badr A. Sulfadiazine crystaluria with urinary tract obstruction. Urol Int. 2001; 66 (3): 173-174. doi: 10.1159/000056792. PMID: 11408794.
[6]	Suri R, Cooper K, O'Riordan A, Thakker RV. Acute renal failure due to sulfadiazine crystal nephropathy. Nephrol Dial Transplant. 1997; 12 (12): 2665-2667. doi: 10.1093/ndt/12.12.2665. PMID: 9449104.
[7]	Dalal N, Nandwani A, Edmonds C, Arora V. Sulfadiazine crystal-induced nephropathy. Clin Kidney J. 2012; 5 (2): 195-196. doi: 10.1093/ckj/sfs005. PMID: 26069850; PMCID: PMC4440714.
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[12]	Orta-Sibu N, Suero E, Palou J, et al. Sulfadiazine-induced crystalluria and renal colic. Scand J Urol Nephrol. 1995; 29 (1): 103-105.
[13]	Haas CA, Brown JM. Sulfadiazine-induced urine crystals. Am J Kidney Dis. 2003; 42 (3): E9-E11.
[14]	Balaraman V, Manickam K, Nagarajan V, Sethumadhavan R. Sulfadiazine-induced obstructive uropathy: a case report. J Med Case Rep. 2012; 6: 120.
[15]	Reddy M, Paul AB, Kapur G, Jayaraman R. Sulfadiazine-induced renal failure in a patient with HIV-associated neurocognitive disorder. BMJ Case Rep. 2016; 2016: bcr2016215087.
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APA Style

Obelleiro Campos Xabier Alexandre. (2023). Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report. Pathology and Laboratory Medicine, 7(2), 24-27. https://doi.org/10.11648/j.plm.20230702.11

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ACS Style

Obelleiro Campos Xabier Alexandre. Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report. Pathol. Lab. Med. 2023, 7(2), 24-27. doi: 10.11648/j.plm.20230702.11

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AMA Style

Obelleiro Campos Xabier Alexandre. Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report. Pathol Lab Med. 2023;7(2):24-27. doi: 10.11648/j.plm.20230702.11

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@article{10.11648/j.plm.20230702.11,
  author = {Obelleiro Campos Xabier Alexandre},
  title = {Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report},
  journal = {Pathology and Laboratory Medicine},
  volume = {7},
  number = {2},
  pages = {24-27},
  doi = {10.11648/j.plm.20230702.11},
  url = {https://doi.org/10.11648/j.plm.20230702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20230702.11},
  abstract = {Background: Sulfonamides are a commonly prescribed class of antibiotics for the treatment of urinary tract infections (UTIs). Sulfadiazine, in particular, has been associated with the formation of crystals in urine, which can lead to kidney stones and urinary tract obstruction. Objective: To report a case of sulfadiazine urine sediment in a patient with a history of recurrent UTIs. Method: We present a case report of a 45-year-old female with a history of recurrent UTIs who presented with the presence of sulfadiazine crystals in her urine sediment. The patient had been prescribed sulfadiazine for a recent UTI and had discontinued the medication as directed by her physician. Urine analysis revealed the presence of numerous sulfadiazine crystals, as well as leukocytes and bacteria. The patient was treated with antibiotics and instructed to drink plenty of fluids. Follow-up urine tests showed the disappearance of the sulfadiazine crystals. Results: The presence of sulfadiazine crystals in urine sediment was detected on routine urine analysis in a patient with a history of recurrent UTIs who had been prescribed sulfadiazine for a recent UTI. The crystals disappeared on follow-up urine tests after treatment with antibiotics and increased fluid intake. Conclusion: Sulfadiazine urine sediment is a rare complication associated with the use of sulfonamides for the treatment of UTIs. Clinicians should be aware of this potential complication and monitor for the presence of sulfadiazine crystals on urine analysis in patients who have been prescribed sulfonamide antibiotics. Appropriate management, including discontinuation of the medication and increased fluid intake, can prevent the development of kidney stones and urinary tract obstruction.},
 year = {2023}
}

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TY - JOUR
T1 - Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report
AU - Obelleiro Campos Xabier Alexandre
Y1 - 2023/09/18
PY - 2023
N1 - https://doi.org/10.11648/j.plm.20230702.11
DO - 10.11648/j.plm.20230702.11
T2 - Pathology and Laboratory Medicine
JF - Pathology and Laboratory Medicine
JO - Pathology and Laboratory Medicine
SP - 24
EP - 27
PB - Science Publishing Group
SN - 2640-4478
UR - https://doi.org/10.11648/j.plm.20230702.11
AB - Background: Sulfonamides are a commonly prescribed class of antibiotics for the treatment of urinary tract infections (UTIs). Sulfadiazine, in particular, has been associated with the formation of crystals in urine, which can lead to kidney stones and urinary tract obstruction. Objective: To report a case of sulfadiazine urine sediment in a patient with a history of recurrent UTIs. Method: We present a case report of a 45-year-old female with a history of recurrent UTIs who presented with the presence of sulfadiazine crystals in her urine sediment. The patient had been prescribed sulfadiazine for a recent UTI and had discontinued the medication as directed by her physician. Urine analysis revealed the presence of numerous sulfadiazine crystals, as well as leukocytes and bacteria. The patient was treated with antibiotics and instructed to drink plenty of fluids. Follow-up urine tests showed the disappearance of the sulfadiazine crystals. Results: The presence of sulfadiazine crystals in urine sediment was detected on routine urine analysis in a patient with a history of recurrent UTIs who had been prescribed sulfadiazine for a recent UTI. The crystals disappeared on follow-up urine tests after treatment with antibiotics and increased fluid intake. Conclusion: Sulfadiazine urine sediment is a rare complication associated with the use of sulfonamides for the treatment of UTIs. Clinicians should be aware of this potential complication and monitor for the presence of sulfadiazine crystals on urine analysis in patients who have been prescribed sulfonamide antibiotics. Appropriate management, including discontinuation of the medication and increased fluid intake, can prevent the development of kidney stones and urinary tract obstruction.
VL - 7
IS - 2
ER -

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Author Information

Obelleiro Campos Xabier Alexandre

Hospital de Palamós, Serveis de Salut Integrats del Baix Empordà, Palamós, Catalunya

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APA Style

Obelleiro Campos Xabier Alexandre. (2023). Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report. Pathology and Laboratory Medicine, 7(2), 24-27. https://doi.org/10.11648/j.plm.20230702.11

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ACS Style

Obelleiro Campos Xabier Alexandre. Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report. Pathol. Lab. Med. 2023, 7(2), 24-27. doi: 10.11648/j.plm.20230702.11

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AMA Style

Obelleiro Campos Xabier Alexandre. Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report. Pathol Lab Med. 2023;7(2):24-27. doi: 10.11648/j.plm.20230702.11

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@article{10.11648/j.plm.20230702.11,
  author = {Obelleiro Campos Xabier Alexandre},
  title = {Sulfadiazine Urine Sediment in a Patient with Recurrent Urinary Tract Infections: A Case Report},
  journal = {Pathology and Laboratory Medicine},
  volume = {7},
  number = {2},
  pages = {24-27},
  doi = {10.11648/j.plm.20230702.11},
  url = {https://doi.org/10.11648/j.plm.20230702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20230702.11},
  abstract = {Background: Sulfonamides are a commonly prescribed class of antibiotics for the treatment of urinary tract infections (UTIs). Sulfadiazine, in particular, has been associated with the formation of crystals in urine, which can lead to kidney stones and urinary tract obstruction. Objective: To report a case of sulfadiazine urine sediment in a patient with a history of recurrent UTIs. Method: We present a case report of a 45-year-old female with a history of recurrent UTIs who presented with the presence of sulfadiazine crystals in her urine sediment. The patient had been prescribed sulfadiazine for a recent UTI and had discontinued the medication as directed by her physician. Urine analysis revealed the presence of numerous sulfadiazine crystals, as well as leukocytes and bacteria. The patient was treated with antibiotics and instructed to drink plenty of fluids. Follow-up urine tests showed the disappearance of the sulfadiazine crystals. Results: The presence of sulfadiazine crystals in urine sediment was detected on routine urine analysis in a patient with a history of recurrent UTIs who had been prescribed sulfadiazine for a recent UTI. The crystals disappeared on follow-up urine tests after treatment with antibiotics and increased fluid intake. Conclusion: Sulfadiazine urine sediment is a rare complication associated with the use of sulfonamides for the treatment of UTIs. Clinicians should be aware of this potential complication and monitor for the presence of sulfadiazine crystals on urine analysis in patients who have been prescribed sulfonamide antibiotics. Appropriate management, including discontinuation of the medication and increased fluid intake, can prevent the development of kidney stones and urinary tract obstruction.},
 year = {2023}
}

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